IVF Ectopic Pregnancies constitute 2.1-8.6% of embryo Transfers.

Ectopic pregnancy following in vitro fertilization with embryo transfer: A single-center experience during 15 years

Ling-Yun Cheng ^a, Pin-Yao Lin ^b, Fu-Jen Huang ^b, Fu-Tsai Kung ^b, Hsin-Ju Chiang ^b, Yu-Ju Lin ^a, Kuo-Chung Lan ^b

The estimated rate of ectopic pregnancy in the general population is 1 to 2%

Abstract

Objective

Ectopic pregnancy is an obstetrical disease that is potentially associated with maternal death in the first trimester.

It is one of the well-known complications following in vitro fertilization (IVF) with embryo transfer (ET).

 The incidence of ectopic pregnancy is estimated to be 2.1–8.6% of clinical pregnancy after IVF-ET, which is higher than natural conceptions (incidence rate 2%).

This study aimed to re-evaluate the ectopic pregnancy rate in patients undergoing IVF-ET and to investigate the effects of embryo stage and frozen–thawed blastocyst transfer and ET during full bladder distention on ectopic pregnancy rate.

Materials and methods

This retrospective study reviewed women who achieved a clinical pregnancy after IVF-ET at the Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital between 1999 and 2013.

We compared ectopic pregnancy rate following Day 3 ET with Day 5 ET, and after fresh ET with thawed ET. Besides, multivariate analysis was used to clarify the factors affecting ectopic pregnancy after IVF-ET.

Conclusion

Thawed ET was not associated with a lower incidence of ectopic pregnancy than fresh ET, and the embryo stage did not affect the rate of ectopic pregnancy. In addition, TET and ET under conditions of full bladder distention may increase the ectopic pregnancy rate.

Research has shown that doing acupuncture post-embryo transfer significantly reduces the potential of an ectopic pregnancy.